http://purl.uniprot.org/citations/4005226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/4005226 | http://www.w3.org/2000/01/rdf-schema#comment | "Connective tissue activating peptide III (CTAP III), a human platelet derived growth factor, induced marked stimulation of 2-deoxy[14C]glucose (2dG) uptake in cultures of human synovial cells, chondrocytes, and dermal fibroblasts. Cytochalasin B (2 X 10(-5) M) blocked the mediator-induced increase in 2dG uptake; phlorhizin (8 X 10(-4) M) partially inhibited this process. When cells were exposed to CTAP III (4 X 10(-6) M) for 30 min prior to uptake assay, 2dG uptake was stimulated by 30-110%; greater stimulation (400-800%) occurred following 17-40-h preincubation with the mediator. A 17-h exposure to CTAP III similarly stimulated 3-O-methylglucose uptake by over 400%, suggesting that CTAP III stimulated 2dG uptake is mediated via changes in hexose transport. Cycloheximide clearly prevented the 17-h effects of CTAP III on 2dG uptake. Insulin (3 X 10(-6) M) stimulated 2dG uptake 40-70% after 30-min preincubation with hormone; little effect was seen after 17-h preincubation. These data suggest that CTAP III stimulates glucose transport shortly after addition to target cells; the major stimulation observed after a 17-h incubation is consistent with the synthesis of new glucose transport protein."xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi00328a029"xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/author | "Castor C.W."xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/author | "Carter-Su C."xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/author | "Furlong A.M."xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/date | "1985"xsd:gYear |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/pages | "1762-1767"xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/title | "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III."xsd:string |
http://purl.uniprot.org/citations/4005226 | http://purl.uniprot.org/core/volume | "24"xsd:string |
http://purl.uniprot.org/citations/4005226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/4005226 |
http://purl.uniprot.org/citations/4005226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/4005226 |
http://purl.uniprot.org/uniprot/P02775#attribution-5C955FF29745BD81933A5DF245ADA1DB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/4005226 |