| http://purl.uniprot.org/citations/6610701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6610701 | http://www.w3.org/2000/01/rdf-schema#comment | "The lymphoproliferation characteristic of all strains of mice homozygous for the gene lpr results from the expansion of an unusual subset of cells that express reduced levels of Ly-1 and Thy-1 antigens and high levels of Ly-5(B220), an antigen that is normally only detected on cells of the B lineage. In the present study, C3H-lpr mice were studied to determine when this population of cells first appears in lymph node (LN) and spleen and whether its appearance relates to the development of B cell activation and deficiencies in interleukin 2 (IL 2) production. The results showed that Ly-5(B220)+, sIg-cells were first detected in LN at 4 wk of age; thereafter their numbers increased exponentially until at 16 wk of age they represented more than 80% of LN cells. Two subpopulations of Ly-5(B220)+, sIg-cells were present in LN; one Ly-1+, Thy-1+ and the other Ly-1+, Thy-1-. Ly-5(B220)+, sIg-cells were not detected in C3H-lpr spleen until 6 to 10 wks after their appearance in LN, and their proportions never reached those in LN. Polyclonal B cell activation in C3H-lpr spleens was not observed until Ly-5(B220)+, sIg-cells were present, suggesting that this population may play a role in B cell stimulation. IL 2 production by C3H-lpr spleen and LN cells was normal up to 6 wk of age and was significantly impaired thereafter, with LN being more severely affected than spleen. The IL 2 defect could be significantly repaired by the addition of PMA to the cultures. Although defective IL 2 production coincided with the appearance of Ly-5(B220)+, sIg-cells in LN, it preceded the appearance of these cells in spleen. In spite of the impaired ability to produce IL 2 in vitro, CTL responses to alloantigens were normal. Although C3H-lpr mice share many of the lymphoid abnormalities observed in MRL-lpr mice, they do not develop severe, early-onset SLE-like disease characteristic of the latter strain. This suggests that factors other than defective IL 2 production and polyclonal B cell activation are required for the development of fulminant autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/author | "Holmes K.L."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/author | "Roths J.B."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/author | "Morse H.C."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/author | "Davidson W.F."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/author | "Rudikoff E."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/date | "1984"xsd:gYear |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/pages | "1048-1056"xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/title | "Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice."xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/6610701 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/6610701 |
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| http://purl.uniprot.org/uniprot/P13379#attribution-DC0503E0CD4C66D458C7FE0CD96B27F7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/6610701 |
| http://purl.uniprot.org/uniprot/P01731#attribution-DC0503E0CD4C66D458C7FE0CD96B27F7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/6610701 |
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| http://purl.uniprot.org/uniprot/P25446#attribution-42534EAA358A1D8CCFC228149BF913BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/6610701 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-6610701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6610701 |
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| http://purl.uniprot.org/uniprot/#_A0A494B9V0-mappedCitation-6610701 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/6610701 |