| http://purl.uniprot.org/citations/6695174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6695174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/6695174 | http://www.w3.org/2000/01/rdf-schema#comment | "A single genetic alteration, a guanine-to-cytosine transversion, is responsible for the acquisition of malignant properties by K-ras genes of two human tumor cell lines established from carcinomas of the bladder (A1698) and lung (A2182). As a consequence, arginine instead of the normal glycine is incorporated into the K-ras-coded p21 proteins at amino acid position 12. This mutation creates a restriction enzyme polymorphism that can be used to screen human cells for transforming K-ras genes. This approach was used to identify the mutational event responsible for the malignant activation of a K-ras oncogene in a squamous cell lung carcinoma of a 66-year-old man; this point mutation was not present in either the normal bronchial or parenchymal tissue or in the blood lymphocytes. Hence, malignant activation of a ras oncogene appears to be specifically associated with the development of a human neoplasm."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.6695174"xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.6695174"xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Santos E."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Santos E."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Barbacid M."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Barbacid M."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Porta G."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Porta G."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Pierotti M.A."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Pierotti M.A."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Reddy P.E."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Reddy P.E."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Martin-Zanca D."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/author | "Martin-Zanca D."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/date | "1984"xsd:gYear |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/date | "1984"xsd:gYear |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/pages | "661-664"xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/pages | "661-664"xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/title | "Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient."xsd:string |
| http://purl.uniprot.org/citations/6695174 | http://purl.uniprot.org/core/title | "Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient."xsd:string |