| http://purl.uniprot.org/citations/7477295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7477295 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7477295 | http://www.w3.org/2000/01/rdf-schema#comment | "ANCHORING of ion channels at specific subcellular sites is critical for neuronal signalling, but the mechanisms underlying channel localization and clustering are largely unknown (reviewed in ref. 1). Voltage-gated K+ channels are concentrated in various neuronal domains, including presynaptic terminals, nodes of Ranvier and dendrites, where they regulate local membrane excitability. Here we present functional and biochemical evidence that cell-surface clustering of Shaker-subfamily K+ channels is mediated by the PSD-95 family of membrane-associated putative guanylate kinases, as a result of direct binding of the carboxy-terminal cytoplasmic tails to the K+ channel subunits to two PDZ (also known as GLGF or DHR) domains in the PSD-95 protein. The ability of PDZ domains to function as independent modules for protein-protein interaction, and their presence in other junction-associated molecules (such as ZO-1 (ref. 3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.org/dc/terms/identifier | "doi:10.1038/378085a0"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.org/dc/terms/identifier | "doi:10.1038/378085a0"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Jan Y.N."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Jan Y.N."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Sheng M."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Sheng M."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Niethammer M."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Niethammer M."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Rothschild A."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/author | "Rothschild A."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/pages | "85-88"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/pages | "85-88"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/title | "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/title | "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases."xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/volume | "378"xsd:string |
| http://purl.uniprot.org/citations/7477295 | http://purl.uniprot.org/core/volume | "378"xsd:string |