| http://purl.uniprot.org/citations/7499264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7499264 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasminogen activator inhibitor type 2 (PAI-2) is a serine proteinase inhibitor or serpin that is a major product of macrophages in response to endotoxin and inflammatory cytokines. We have explored the role of PAI-2 in apoptotic cell death initiated by tumor necrosis factor alpha (TNF). HeLa cells stably transfected with PAI-2 cDNA were protected from TNF-induced apoptosis, whereas cells transfected with antisense PAI-2 cDNA, a control gene, or the plasmid vector alone remained susceptible. The level of PAI-2 expressed by different HeLa cell clones was inversely correlated with their sensitivity to TNF. Loss of TNF sensitivity was not a result of loss of TNF receptor binding. In contrast, PAI-2 expression did not confer protection against apoptosis induced by ultraviolet or ionizing radiation. The serine proteinase urokinase-type plasminogen activator was not demonstrated to be the target of PAI-2 action. The P1-Arg amino acid residue of PAI-2 was determined to be required for protection, because cells expressing PAI-2 with an Ala in this position were not protected from TNF-mediated cell death. The results suggest that intracellular PAI-2 might be an important factor in regulating cell death in TNF-mediated inflammatory processes through inhibition of a proteinase involved in TNF-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.46.27894"xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/author | "Antalis T.M."xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/author | "Ferrante A."xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/author | "Dickinson J.L."xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/author | "Bates E.J."xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/pages | "27894-27904"xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/title | "Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function."xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7499264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7499264 |
| http://purl.uniprot.org/citations/7499264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7499264 |
| http://purl.uniprot.org/uniprot/P05120#attribution-5114C5A0B9F7EFF238AE40D9AB1E0142 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7499264 |