| http://purl.uniprot.org/citations/7512451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7512451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7512451 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute-phase response factor (APRF) is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. We report here the purification and cloning of APRF. APRF exhibits a 52.5% overall homology at the amino acid level with p91, a component of the interferon (IFN)-stimulated gene factor 3 complexes. The cloned APRF protein is tyrosine phosphorylated and translocated into the nucleus in response to IL-6, but not in response to IFN-gamma. Tyrosine phosphorylation was also observed in response to other cytokines, such as leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor, whose receptors share the IL-6 receptor signal transducer gp130. In contrast, we observed that p91 is not tyrosine phosphorylated in response to IL-6. These results suggest that this novel p91-related protein may play a major role in the gp130-mediated signaling pathway and that selective activation of p91-related factors may explain the diversity of cellular responses to different cytokines."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90235-6"xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90235-6"xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Inoue M."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Inoue M."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Nishio Y."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Nishio Y."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Kishimoto T."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Wei S."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Wei S."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Yoshida K."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Wang X.-J."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Wang X.-J."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Sudo T."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Sudo T."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Matsusaka T."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Matsusaka T."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Naruto M."xsd:string |
| http://purl.uniprot.org/citations/7512451 | http://purl.uniprot.org/core/author | "Naruto M."xsd:string |