| http://purl.uniprot.org/citations/7518616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7518616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7518616 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) family members bind to receptors that consist of heteromeric serine-threonine kinase subunits (type I and type II). In a yeast genetic screen, the immunophilin FKBP-12, a target of the macrolides FK506 and rapamycin, interacted with the type I receptor for TGF-beta and with other type I receptors. Deletion, point mutation, and co-immunoprecipitation studies further demonstrated the specificity of the interaction. Excess FK506 competed with type I receptors for binding to FKBP-12, which suggests that these receptors share or overlap the macrolide binding site on FKBP-12, and therefore they may represent its natural ligand. The specific interaction between the type I receptors and FKBP-12 suggests that FKBP-12 may play a role in type I receptor-mediated signaling."xsd:string |
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| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/author | "Zervos A.S."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/author | "Zervos A.S."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/author | "Donahoe P.K."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/author | "Donahoe P.K."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/pages | "674-676"xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/pages | "674-676"xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/title | "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/title | "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12."xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/7518616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7518616 |
| http://purl.uniprot.org/citations/7518616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7518616 |
| http://purl.uniprot.org/citations/7518616 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7518616 |
| http://purl.uniprot.org/citations/7518616 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7518616 |