| http://purl.uniprot.org/citations/7521882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7521882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7521882 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood group antigens are structural variants in surface carbohydrate or amino acid polymorphisms on extracellular domains of membrane proteins. The red cell water channel-forming integral protein (Aquaporin CHIP) is a homotetramer with only one N-glycosylated subunit, however no CHIP-associated blood group antigens have yet been identified. Immunoblotting, monosaccharide composition analysis, and selective glycosidase digestions revealed that the CHIP-associated oligosaccharide contains ABH determinants and resembles a band 3-type glycan that cannot be cleaved from intact membranes by Peptide:N-glycosidase F. The molecular structure of the Colton antigens was previously unknown, but CHIP was selectively immunoprecipitated with anti-Coa or anti-Co(b). The DNA sequence from Colton-typed individuals predicted that residue 45 is alanine in the Co(a+b-) phenotype and valine in the Co(a-b+) phenotype. The nucleotide polymorphism corresponds to a PflMI endonuclease digestion site in the DNA from Co(a-b+) individuals. These studies have defined antigens within two blood group systems on CHIP: (a) an ABH-bearing polylactosaminoglycan attached to a poorly accessible site in the native membrane; and (b) the Colton antigen polymorphism which may permit the identification of rare individuals with defective water channel expression."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci117418"xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci117418"xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Preston G.M."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Preston G.M."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Agre P."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Agre P."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Anstee D.J."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Anstee D.J."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Smith B.L."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Smith B.L."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Spring F."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/author | "Spring F."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/name | "J. Clin. Invest."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/name | "J. Clin. Invest."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/pages | "1043-1049"xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/pages | "1043-1049"xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/title | "Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/title | "Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens."xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/7521882 | http://purl.uniprot.org/core/volume | "94"xsd:string |