| http://purl.uniprot.org/citations/7542657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7542657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7542657 | http://www.w3.org/2000/01/rdf-schema#comment | "Centromere protein-F (CENP-F) is mammalian kinetochore protein that was recently identified by an autoimmune serum (Rattner, J. B., A. Rao, M. J. Fritzler, D. W. Valencia, and T. J. Yen. Cell Motil. Cytoskeleton. 26:214-226). We report here the human cDNA sequence of CENP-F, along with its expression and localization patterns at different stages of the HeLa cell cycle. CENP-F is protein of the nuclear matrix that gradually accumulates during the cell cycle until it reaches peak levels in G2 and M phase cells and is rapidly degraded upon completion of mitosis. CENP-F is first detected at the prekinetochore complex during late G2, and is clearly detectable as paired foci that correspond to all the centromeres by prophase. During mitosis, CENP-F is associated with kinetochores from prometaphase until early anaphase and is then detected at the spindle midzone throughout the remainder of anaphase. By telophase, CENP-F is concentrated within the intracellular bridge at either side of the mid-body. The predicted structure of the 367-kD CENP-F protein consists of two 1,600-amino acid-long coil domains that flank a central flexible core. A putative P-loop nucleotide binding site (ADIPTGKT) is located within the globular carboxy terminus. The structural features deduced from our sequence studies and the spatial and temperal distribution of CENP-F revealed in our cytological and biochemical studies suggest that it may play a role in several mitotic events."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.130.3.507"xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.130.3.507"xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Winkfein R.J."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Winkfein R.J."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Liao H."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Liao H."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Yen T.J."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Yen T.J."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Rattner J.B."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Rattner J.B."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Mack G."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/author | "Mack G."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/pages | "507-518"xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/pages | "507-518"xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/title | "CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/title | "CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis."xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/7542657 | http://purl.uniprot.org/core/volume | "130"xsd:string |