http://purl.uniprot.org/citations/7557101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7557101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/7557101 | http://www.w3.org/2000/01/rdf-schema#comment | "Background & aimsCalmodulin-dependent protein kinase II is a family of closely related multimeric enzymes that regulate a wide variety of cellular processes. In biliary epithelial cells, this kinase seems to regulate Ca(2+)-dependent CI-currents. The aim of this study was to identify isoforms of this kinase expressed in biliary cells.MethodsSequencing of reverse-transcription polymerase chain reaction products identified multiple isoforms in Mz-ChA-1 cells.ResultsTwo previously identified isoforms (gamma B and gamma C) and three new isoforms (gamma D, gamma E, and gamma F) of calmodulin-dependent protein kinase II were identified. Each of the novel isoforms contains a unique insert of 114 base pairs in the association region. This insert lies outside the previously identified variable region. In addition, gamma D and gamma F contained other deletions (42 and 69 base pairs, respectively) in the variable region. These isoforms are expressed in a variety of tissues, including biliary epithelial and gallbladder cells, but only gamma C is expressed in rat hepatocytes.ConclusionsIdentification of these biliary kinase isoforms paves the way for future studies that will elucidate the role of individual isozymes in agonist-stimulated biliary Cl- and fluid secretion."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.org/dc/terms/identifier | "doi:10.1016/0016-5085(95)90594-4"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.org/dc/terms/identifier | "doi:10.1016/0016-5085(95)90594-4"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/author | "Kwiatkowski A.P."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/author | "Kwiatkowski A.P."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/author | "McGill J.M."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/author | "McGill J.M."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/name | "Gastroenterology"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/name | "Gastroenterology"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/pages | "1316-1323"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/pages | "1316-1323"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/title | "Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/title | "Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II."xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/volume | "109"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://purl.uniprot.org/core/volume | "109"xsd:string |
http://purl.uniprot.org/citations/7557101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7557101 |
http://purl.uniprot.org/citations/7557101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7557101 |
http://purl.uniprot.org/citations/7557101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7557101 |
http://purl.uniprot.org/citations/7557101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7557101 |
http://purl.uniprot.org/uniprot/Q13555 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/7557101 |
http://purl.uniprot.org/uniprot/Q13555#attribution-3D4796131EA018E9623A90E19EA03024 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7557101 |