| http://purl.uniprot.org/citations/7592911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7592911 | http://www.w3.org/2000/01/rdf-schema#comment | "The pancreatic polypeptide family includes pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY). Members of the PP family regulate numerous physiological processes, including appetite, gastrointestinal transit, anxiety, and blood pressure. Of the multiple Y-type receptors proposed for PP family members, only the Y1 subtype has been cloned previously. We now report the cloning of an additional Y-type receptor, designated Y4, by homology screening of a human placental genomic library with transmembrane (TM) probes derived from the rat Y1 gene. The Y4 genomic clone encodes a predicted protein of 375 amino acids that is most homologous to Y1 receptors from human, rat, and mouse (42% overall; 55% in TM). 125I-PYY binding to transiently expressed Y4 receptors was saturable (pKd = 9.89) and displaceable by human PP family derivatives: PP (pKi = 10.25) approximately PP2-36 (pKi = 10.06) > PYY (pKi = 9.06) approximately [Leu31,Pro34]NPY (pKi = 8.95) > NPY (pKi = 8.68) > PP13-36 (pKi = 7.13) > PP31-36 (pKi = 6.46) > PP31-36 free acid (pKi < 5). Human PP decreased [cAMP] and increased intracellular [Ca2+] in Y4-transfected LMTK-cells. Y4 mRNA was detected by reverse transcriptase-polymerase chain reaction in human brain, coronary artery, and ileum, suggesting potential roles for Y4 receptors in central nervous system, cardiovascular, and gastrointestinal function."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.45.26762"xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.45.26762"xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Bard J.A."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Bard J.A."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Branchek T.A."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Branchek T.A."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Weinshank R.L."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Weinshank R.L."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Walker M.W."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/author | "Walker M.W."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/pages | "26762-26765"xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/pages | "26762-26765"xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/title | "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/title | "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY."xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/7592911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7592911 |
| http://purl.uniprot.org/citations/7592911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7592911 |