| http://purl.uniprot.org/citations/7595232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7595232 | http://www.w3.org/2000/01/rdf-schema#comment | "We have recently described a monoclonal antibody (mAb) 4G4 recognizing a 70-kD molecule constitutively expressed on human endothelial cells and on subpopulations of lymphocytes. We showed that this molecule, which we named lymphocyte-vascular adhesion protein 2 (L-VAP-2), mediates lymphocyte adhesion to cultured endothelial cells. Protein sequencing of tryptic peptides from immunoaffinity-purified L-VAP-2 revealed sequence identity between L-VAP-2 and CD73 (ecto-5'-nucleotidase, E.C.3.1.3.5), and COS cells transfected with a CD73 cDNA were positively stained with the mAb 4G4, which recognizes L-VAP-2. mAb 4G4 was also able to partially inhibit the ecto-5'-nucleotidase activity of peripheral blood lymphocytes. Moreover, cross-precipitation studies performed with mAb 4G4 and a CD73 workshop mAb 1E9 showed that these two antibodies recognize the same molecule. Since the tissue distribution and biochemical characteristics of the two molecules are also similar, we conclude that L-VAP-2 and CD73 are the same glycoprotein. Adhesion experiments showed significantly increased binding of freshly isolated lymphocytes to COS cells transfected with a CD73 cDNA, as compared to mock-transfected COS cells, and binding of lymphocytes to CD73-expressing COS cells was inhibited by the presence of mAb 4G4 in the adhesion assay. CD73 is a glycosyl phosphatidylinositol-linked molecule previously shown to have a cosignalling role in T lymphocyte proliferation. Our data suggest that it also has a function in mediating lymphocyte adhesion to the endothelium."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.182.5.1603"xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Smith D.J."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Hellman J."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Bono P."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Jalkanen S."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Salmi M."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Airas L."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/author | "Puurunen T."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/pages | "1603-1608"xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/title | "CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73."xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/7595232 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7595232 |
| http://purl.uniprot.org/citations/7595232 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7595232 |
| http://purl.uniprot.org/uniprot/P21589#attribution-74F8184536835A20EA3BA20EA8A59CE2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7595232 |