| http://purl.uniprot.org/citations/7623826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7623826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7623826 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon heat stress, monomeric human heat shock transcription factor 1 (hHSF1) is converted to a trimer, acquires DNA-binding ability, is transported to the nucleus, and becomes transcriptionally competent. It was not known previously whether these regulatory changes are caused by a single activation event or whether they occur independently from one another, providing a multilayered control that may prevent inadvertant activation of hHSF1. Comparison of wild-type and mutant hHSF1 expressed in Xenopus oocytes and human HeLa cells suggested that retention of hHSF1 in the monomeric form depends on hydrophobic repeats (LZ1 to LZ3) and a carboxy-terminal sequence element in hHSF1 as well as on the presence of a titratable factor in the cell. Oligomerization of hHSF1 appears to induce DNA-binding activity as well as to uncover an amino-terminally located nuclear localization signal. A mechanism distinct from that controlling oligomerization regulates the transcriptional competence of hHSF1. Components of this mechanism were mapped to a region, including LZ2 and nearby sequences downstream from LZ2, that is clearly separated from the carboxy-terminally located transcription activation domain(s). We propose the existence of a fold-back structure that masks the transcription activation domain in the unstressed cell but is opened up by modification of hHSF1 and/or binding of a factor facilitating hHSF1 unfolding in the stressed cell. Activation of hHSF1 appears to involve at least two independently regulated structural transitions."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.15.8.4319"xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.15.8.4319"xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/author | "Zuo J."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/author | "Zuo J."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/author | "Rungger D."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/author | "Rungger D."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/author | "Voellmy R."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/author | "Voellmy R."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/pages | "4319-4330"xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/pages | "4319-4330"xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/title | "Multiple layers of regulation of human heat shock transcription factor 1."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/title | "Multiple layers of regulation of human heat shock transcription factor 1."xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/7623826 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7623826 |
| http://purl.uniprot.org/citations/7623826 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7623826 |
| http://purl.uniprot.org/citations/7623826 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7623826 |
| http://purl.uniprot.org/citations/7623826 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7623826 |