| http://purl.uniprot.org/citations/7651733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7651733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7651733 | http://www.w3.org/2000/01/rdf-schema#comment | "The Oct transcription factors N-Oct-3 and N-Oct-5 are differentially expressed in normal melanocytes, melanoma tumors and cell lines. We have cloned the human brn-2 gene and have shown that it encodes both the N-Oct-3 and N-Oct-5 octamer binding activities detected in melanoma cells. The brn-2 genomic locus has been mapped to chromosome 6q16 and although chromosomal aberrations are common in this region in melanoma, no deletion or rearrangement of the brn-2 gene in melanoma cell lines was observed. Sequencing of the entire gene showed that there are no intervening sequences within the open reading frame. Antisense RNA-mediated inhibition of brn-2 gene expression in melanoma cells was associated with a change in morphology and loss of melanocytic and neural crest markers, including the melanocyte transcription factor microphthalmia and the TYRP pigmentation genes. In addition, loss of brn-2 in these cells resulted in the complete loss of ability to form tumors in SCID and nu/nu mice. These results suggest roles for brn-2 in the determination of the melanocytic lineage and in the tumorigenic phenotype of melanoma."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Murphy K."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Murphy K."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Baker E."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Baker E."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Sutherland G.R."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Sutherland G.R."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Sturm R.A."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Sturm R.A."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Angus J."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Angus J."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Parsons P.G."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Parsons P.G."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Thomson F."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/author | "Thomson F."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/pages | "691-700"xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/pages | "691-700"xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/title | "The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/7651733 | http://purl.uniprot.org/core/title | "The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells."xsd:string |