| http://purl.uniprot.org/citations/7665913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7665913 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian melanins exist in two chemically distinct forms: the brown to black eumelanins and the yellow to reddish pheomelanins. Melanogenesis is influenced by a number of genes, the levels of whose products determine the quantity and quality of the melanins produced. To examine the effects of various coat-color genes on the chemical properties of melanins synthesized in the follicular melanocytes of mice, we have introduced new methods to solubilize differentially pheomelanins and brown-type eumelanins. We applied these and previously developed high-performance liquid chromatography and spectrophotometric methods for assaying eu- and pheomelanins to characterize melanins in various mutant mice: black, lethal yellow, viable yellow, agouti, brown, light, albino, dilute, recessive yellow, pink-eyed dilution, slaty, and silver. It was demonstrated that 1) complete solubilization of melanins in Soluene-350 is a convenient method to estimate the total amount of eu- and pheomelanins, 2) lethal yellow, viable yellow, and recessive yellow hairs contain almost pure pheomelanins, and 3) melanins from brown, light, silver, and pink-eyed black hairs share chemical properties in common that are characterized by partial solubility in strong alkali. We suggest that 1) the brown-type eumelanins have lower degrees of polymerization than the black-type eumelanins, and 2) slaty hair melanin contains a greatly reduced ratio of 5,6-dihydroxyindole-2-carboxylic acid-derived units as compared with black and other eumelanic hair melanins. These results indicate that our methodology, high-performance liquid chromatography and spectrophotometric methods combined, may be useful in chemically characterizing melanin pigments produced in follicular melanocytes."xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.org/dc/terms/identifier | "doi:10.1111/1523-1747.ep12320792"xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/author | "Ozeki H."xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/author | "Wakamatsu K."xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/author | "Hirobe T."xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/pages | "361-366"xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/title | "Chemical characterization of hair melanins in various coat-color mutants of mice."xsd:string |
| http://purl.uniprot.org/citations/7665913 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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| http://purl.uniprot.org/uniprot/Q01727#attribution-BF8EFA87ECB11CA5C2F36D0E68046B9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7665913 |
| http://purl.uniprot.org/uniprot/Q99104#attribution-BF8EFA87ECB11CA5C2F36D0E68046B9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7665913 |
| http://purl.uniprot.org/uniprot/Q60696#attribution-BF8EFA87ECB11CA5C2F36D0E68046B9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7665913 |
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| http://purl.uniprot.org/uniprot/P07147#attribution-BF8EFA87ECB11CA5C2F36D0E68046B9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7665913 |
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| http://purl.uniprot.org/uniprot/P11344#attribution-BF8EFA87ECB11CA5C2F36D0E68046B9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7665913 |
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