| http://purl.uniprot.org/citations/7684160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7684160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7684160 | http://www.w3.org/2000/01/rdf-schema#comment | "Antigen receptors on B and T lymphocytes transduce signals by activating nonreceptor protein tyrosine kinases (PTKs). A family of receptor PTKs contains kinase insert regions with the sequence tyrosine-X-X-methionine (where X is any amino acid) that when phosphorylated mediate the binding and activation of phosphatidylinositol 3-kinase (PI 3-kinase). The CD19 membrane protein of B cells enhances activation through membrane immunoglobulin M (mIgM) and was found to contain a functional analog of the kinase insert region. Ligation of mIgM induced phosphorylation of CD19 and association with PI 3-kinase. Thus, CD19 serves as a surrogate kinase insert region for mIgM by providing the means for PI 3-kinase activation by nonreceptor PTKs."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.7684160"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.7684160"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Tuveson D.A."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Tuveson D.A."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Carter R.H."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Carter R.H."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Fearon D.T."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Soltoff S.P."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/author | "Soltoff S.P."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/pages | "986-989"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/pages | "986-989"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/title | "CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/title | "CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase."xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/volume | "260"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://purl.uniprot.org/core/volume | "260"xsd:string |
| http://purl.uniprot.org/citations/7684160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7684160 |
| http://purl.uniprot.org/citations/7684160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7684160 |