| http://purl.uniprot.org/citations/7715705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7715705 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease is the most common cause of progressive intellectual failure. The lesions that develop, called senile plaques, are extracellular deposits principally composed of insoluble aggregates of beta-amyloid protein (A beta), infiltrated by reactive microglia and astrocytes. Although A beta, and a portion of it, the fragment 25-35 (A beta (25-35)), have been shown to exert a direct toxic effect on neurons, the role of microglia in such neuronal injury remains unclear. Here we report a synergistic effect between A beta and interferon-gamma (IFN-gamma) in triggering the production of reactive nitrogen intermediates and tumour-necrosis factor-alpha (TNF-alpha) from microglia. Furthermore, using co-culture experiments, we show that activation of microglia with IFN-gamma and A beta leads to neuronal cell injury in vitro. These findings suggest that A beta and IFN-gamma activate microglia to produce reactive nitrogen intermediates and TNF-alpha, and this may have a role in the pathogenesis of neuronal degeneration observed in ageing and Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.org/dc/terms/identifier | "doi:10.1038/374647a0"xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Ferrari D."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Villalba M."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Rossi F."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Baron P."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Otvos L. Jr."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Cassatella M.A."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Meda L."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/author | "Szendrei G.I."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/pages | "647-650"xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/title | "Activation of microglial cells by beta-amyloid protein and interferon-gamma."xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://purl.uniprot.org/core/volume | "374"xsd:string |
| http://purl.uniprot.org/citations/7715705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7715705 |
| http://purl.uniprot.org/citations/7715705 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7715705 |
| http://purl.uniprot.org/uniprot/P01580#attribution-447F4095083C0BCE7242A7206A877328 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7715705 |
| http://purl.uniprot.org/uniprot/P01579#attribution-447F4095083C0BCE7242A7206A877328 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7715705 |
| http://purl.uniprot.org/uniprot/P01579#attribution-7C2B29504E753AF4ECB47DDE12F36F54 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7715705 |
| http://purl.uniprot.org/uniprot/P06804#attribution-447F4095083C0BCE7242A7206A877328 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/7715705 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-7715705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715705 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-7715705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715705 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-7715705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/7715705 |