| http://purl.uniprot.org/citations/7736590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7736590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7736590 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified an essential gene, called FIP1, encoding a 327 amino acid protein interacting with yeast poly(A) polymerase (PAP1) in the two-hybrid assay. Recombinant FIP1 protein forms a 1:1 complex with PAP1 in vitro. At 37 degrees C, a thermosensitive allele of FIP1 shows a shortening of poly(A) tails and a decrease in the steady-state level of actin transcripts. When assayed for 3'-end processing in vitro, fip1 mutant extracts exhibit normal cleavage activity, but fail to polyadenylate the upstream cleavage product. Polyadenylation activity is restored by adding polyadenylation factor I (PF I). Antibodies directed against FIP1 specifically recognize a polypeptide in these fractions. Coimmunoprecipitation experiments reveal that RNA14, a subunit of cleavage factor I (CF I), directly interacts with FIP1, but not with PAP1. We propose a model in which PF I tethers PAP1 to CF I, thereby conferring specificity to poly(A) polymerase for pre-mRNA substrates."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90391-7"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(95)90391-7"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Keller W."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Keller W."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Lingner J."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Lingner J."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Minvielle-Sebastia L."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Minvielle-Sebastia L."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Preker P.J."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/author | "Preker P.J."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/pages | "379-389"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/pages | "379-389"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/title | "The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/title | "The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase."xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/7736590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7736590 |
| http://purl.uniprot.org/citations/7736590 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7736590 |