| http://purl.uniprot.org/citations/7813445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7813445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7813445 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. In mammals several classes of cyclins exist which are thought to co-ordinate the timing of different events necessary for cell cycle progression. Here we describe the identification of a novel human cyclin, cyclin F, isolated as a suppressor of the G1/S deficiency of a Saccharomyces cerevisiae cdc4 mutant. Cyclin F is the largest cyclin, with a molecular weight of 87 kDa, and migrates as a 100-110 kDa protein. It contains an extensive PEST-rich C-terminus and a cyclin box region that is most closely related to cyclins A and B. Cyclin F mRNA is ubiquitiously expressed in human tissues. It fluctuates dramatically through the cell cycle, peaking in G2 like cyclin A and decreasing prior to decline of cyclin B mRNA. Cyclin F protein accumulates in interphase and is destroyed at mitosis at a time distinct from cyclin B. Cyclin F shows regulated subcellular localization, being localized in the nucleus in most cells, with a significant percentage of cells displaying only perinuclear staining. Overexpression of cyclin F, or a mutant lacking the PEST region, in human cells resulted in a significant increase in the G2 population, implicating cyclin F in the regulation of cell cycle transitions. The ubiquitous expression and phylogentic conservation of cyclin F suggests that it is likely to coordinate essential cell cycle events distinct from those regulated by other cyclins."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06955.x"xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06955.x"xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/author | "Elledge S.J."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/author | "Bai C."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/author | "Bai C."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/author | "Richman R."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/author | "Richman R."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/pages | "6087-6098"xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/pages | "6087-6098"xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/title | "Human cyclin F."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/title | "Human cyclin F."xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/7813445 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7813445 |
| http://purl.uniprot.org/citations/7813445 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7813445 |
| http://purl.uniprot.org/citations/7813445 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7813445 |
| http://purl.uniprot.org/citations/7813445 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7813445 |