| http://purl.uniprot.org/citations/7836910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7836910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7836910 | http://www.w3.org/2000/01/rdf-schema#comment | "The production of cytokines in monocytes/macrophages is regulated by several different cytokines that have activating or inhibitory effects. Interleukin (IL)-10, IL-4, IL-13, and transforming growth factor (TGF)-beta are usually considered to be the most important macrophage-deactivating factors, with inhibitory effects on cytokine production. Unlike IL-10 and TGF-beta, which appear to act as downmodulators of many phagocytic cell functions, the mode of action of IL-4 and IL-13 is more complex. Addition of IL-4 and IL-13 to peripheral blood mononuclear cell (PBMC) cultures inhibited production of IL-12, tumor necrosis factor (TNF)-alpha, IL-10, and IL-1 beta induced by lipopolysaccharide (LPS) or Staphylococcus aureus added simultaneously with the cytokines. However, pretreatment of PBMC with IL-4 or IL-13 for > or = 20 h enhanced the production of IL-12 and TNF-alpha in response to LPS or S. aureus several fold in these cells; this IL-4-induced priming for the two cytokines was inhibited by anti-IL-4 neutralizing antibodies. IL-4 priming also enhanced the accumulation of IL-12 and TNF-alpha mRNA induced by LPS and S. aureus. The enhanced accumulation of transcripts for the IL-12 p35 and p40 chains by IL-4 priming was reflected in enhanced secretion of both the IL-12 free p40 chain and the p70 heterodimer. These results suggest an unexpected complexity in the regulatory role of IL-4 and IL-13 in immune responses."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.181.2.537"xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.181.2.537"xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Trinchieri G."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Trinchieri G."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "D'Andrea A."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "D'Andrea A."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Aste-Amezaga M."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Aste-Amezaga M."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Paganin C."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/author | "Paganin C."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/pages | "537-546"xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/pages | "537-546"xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/title | "Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/title | "Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production."xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/7836910 | http://purl.uniprot.org/core/volume | "181"xsd:string |