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http://purl.uniprot.org/citations/7898930http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7898930http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/7898930http://www.w3.org/2000/01/rdf-schema#comment"We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence similarity to the extracellular (ligand-binding domain of platelet-derived growth factor receptor beta, we have designated it PRLTS (PDGF-receptor beta-like tumor suppressor). Structural rearrangement involving this gene was found in a sporadic NSCLC. In addition, somatic missense and frame-shift mutations were found in two HCCs and one CRC. These findings indicate that inactivation of the PRLTS gene may play a significant role in development of some carcinomas."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Fujiwara Y."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Fujiwara Y."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Kuroki T."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Kuroki T."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Nakamura Y."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Nakamura Y."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Tsuchiya E."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Tsuchiya E."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Koyama K."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Koyama K."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Monden M."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Monden M."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Ohata H."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/author"Ohata H."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/date"1995"xsd:gYear
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/name"Oncogene"xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/name"Oncogene"xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/pages"891-895"xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/pages"891-895"xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/title"Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene."xsd:string
http://purl.uniprot.org/citations/7898930http://purl.uniprot.org/core/title"Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene."xsd:string