| http://purl.uniprot.org/citations/7930580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7930580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7930580 | http://www.w3.org/2000/01/rdf-schema#comment | "CD39, a 70-to 100-kDa molecule expressed primarily on activated lymphoid cells, was previously shown to mediate B cell homotypic adhesion when ligated with a subset of anti-CD39 mAbs. In the present study, we describe the cloning and molecular characterization of human and murine CD39. The nucleotide sequence of human CD39 includes an open reading frame encoding a putative 510 amino acid protein with six potential N-linked glycosylation sites, 11 Cys residues, and two potential transmembrane regions. Murine CD39 shares 75% amino acid sequence identity with human CD39 but fails to cross-react with anti-human CD39 mAbs. Although there were no significant similarities with other mammalian genes, considerable homology was found between CD39 and a guanosine diphosphatase from yeast. A series of mouse-human hybrid molecules was constructed to determine the general topology of CD39 and the location of a biologically functional epitope. These findings and supporting evidence from an anti-CD39 mAb-selected phage peptide display library indicate a likely model wherein a short intracellular N-terminus is followed by a large extracellular loop containing the epitope recognized by stimulatory anti-CD39 mAbs, and a short intracellular C terminus. The results demonstrate that CD39 is a novel cell surface glycoprotein with unusual structural characteristics."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Armitage R.J."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Armitage R.J."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Baker E."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Baker E."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Sutherland G.R."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Sutherland G.R."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Poindexter K."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Poindexter K."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Maliszewski C.R."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Maliszewski C.R."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Fanslow W.C."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Fanslow W.C."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Friend D."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Friend D."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Gimpel S.D."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Gimpel S.D."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Schoenborn M.A."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Schoenborn M.A."xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Gayle R.B. III"xsd:string |
| http://purl.uniprot.org/citations/7930580 | http://purl.uniprot.org/core/author | "Gayle R.B. III"xsd:string |