| http://purl.uniprot.org/citations/7937872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7937872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7937872 | http://www.w3.org/2000/01/rdf-schema#comment | "cDNA encoding a receptor-like protein-tyrosine-phosphatase (PTP) termed DEP-1 was isolated from a HeLa cell library. The cDNA predicts an enzyme consisting of an extracellular segment containing eight fibronectin type III repeats, a single transmembrane segment, and a single intracellular PTP domain. Following expression of DEP-1 cDNA in COS cells a glycoprotein of 180 kDa was detected and PTP activity was demonstrated in immunocomplexes with a C-terminal peptide antiserum. Endogenous DEP-1 was detected in WI-38 human embryonic lung fibroblasts by immunoblotting and immunocomplex PTP assays. Immunoblot analysis of DEP-1 expression in WI-38 cells revealed dramatically increased levels and activity of the PTP in dense cultures relative to sparse cultures. Also, DEP-1 activity, detected in PTP assays of immunocomplexes, was increased in dense cell cultures. In contrast, the expression levels of PTP-1B did not change with cell density. This enhancement of DEP-1 expression with increasing cell density was also observed in another fibroblast cell line, AG1518. The increase in DEP-1 occurs gradually with increasing cell contact and is initiated before saturation cell density is reached. These observations suggest that DEP-1 may contribute to the mechanism of contact inhibition of cell growth."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.21.9680"xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.21.9680"xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/author | "Oestman A."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/author | "Oestman A."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/author | "Tonks N.K."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/author | "Tonks N.K."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/pages | "9680-9684"xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/pages | "9680-9684"xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/title | "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/title | "Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density."xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/7937872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7937872 |
| http://purl.uniprot.org/citations/7937872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7937872 |
| http://purl.uniprot.org/citations/7937872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7937872 |
| http://purl.uniprot.org/citations/7937872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/7937872 |