| http://purl.uniprot.org/citations/8084451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8084451 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8084451 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased incidence of infection in uraemic patients is mainly caused by granulocyte dysfunction. Recently we discovered a granulocyte inhibitory protein (GIP I) in the ultrafiltrate of haemodialysis patients, that inhibits four fundamental functions of polymorphonuclear leukocytes (PMNLs). We now report on the isolation of a further polypeptide in end-stage renal disease patient ultrafiltrate using a polyamide filter with biological activity inhibiting healthy PMNL function in vitro. This protein (GIP II) has a molecular weight of about 9500 Da. In-vitro nanomolar concentrations inhibit PMNL O2-production and glucose uptake stimulated by phorbol-myristate-acetate (PMA), but not by formyl-methionyl-leucyl-phenylalanine (FMLP). In-vitro studies were performed to compare the effects of GIP I and GIP II on several PMNL functions. In contrast to GIP II, GIP I inhibits only FMLP-, but not PMA-stimulated PMNL glucose uptake. The NH2 terminal amino acid sequence (21 amino acids) of GIP II shows homology to beta 2-microglobulin. Commercially available intact beta 2-microglobulin had no effect on PMNL glucose uptake and O2-production. The beta 2-microglobulin homologue protein isolated from plasma ultrafiltrates of uraemic patients cross-reacts with three different commercially available assays for intact beta 2-microglobulin. Therefore, beta 2-microglobulin levels measured in the plasma ultrafiltrates of regular haemodialysis patients are overestimated with contribution of an uncertain amount of the beta 2-microglobulin homologue protein (GIP II)."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/author | "Mai B."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/author | "Mai B."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/author | "Hoerl W.H."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/author | "Hoerl W.H."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/author | "Haag-Weber M."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/author | "Haag-Weber M."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/name | "Nephrol. Dial. Transplant."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/name | "Nephrol. Dial. Transplant."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/pages | "382-388"xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/pages | "382-388"xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/title | "Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/title | "Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin."xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/8084451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8084451 |
| http://purl.uniprot.org/citations/8084451 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8084451 |
| http://purl.uniprot.org/citations/8084451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8084451 |
| http://purl.uniprot.org/citations/8084451 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8084451 |
| http://purl.uniprot.org/uniprot/P61769 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8084451 |
| http://purl.uniprot.org/uniprot/#_kb.P61769_up.isolatedFrom_tissue.800 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8084451 |