| http://purl.uniprot.org/citations/8107808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8107808 | http://www.w3.org/2000/01/rdf-schema#comment | "Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin has been reported to bind to the synthetic peptide KLGFFKR, which is almost identical to an amino-acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Could calreticulin interact with the DNA-binding domain of these receptors and affect their function? Here we report that the amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Overexpression of calreticulin in mouse L fibroblasts inhibits glucocorticoid-response-mediated transcriptional activation of a glucocorticoid-sensitive reporter gene and of the endogenous, glucocorticoid-sensitive gene encoding cytochrome P450. Together these results indicate that calreticulin may be important in gene transcription, regulating the glucocorticoid receptor and perhaps other members of the super-family of nuclear receptors."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.org/dc/terms/identifier | "doi:10.1038/367476a0"xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Nemer M."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Michalak M."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Bleackley R.C."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Atkinson E.A."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Duggan B."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/author | "Famulski K.S."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/pages | "476-480"xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/title | "Modulation of gene expression by calreticulin binding to the glucocorticoid receptor."xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://purl.uniprot.org/core/volume | "367"xsd:string |
| http://purl.uniprot.org/citations/8107808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8107808 |
| http://purl.uniprot.org/citations/8107808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8107808 |
| http://purl.uniprot.org/uniprot/P27797#attribution-4746CA5E7B8AD0CEB01776EB7CCA3A6E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/#_B2MWM9-mappedCitation-8107808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/#_P14211-mappedCitation-8107808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/#_Q3UWP8-mappedCitation-8107808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/#_Q62041-mappedCitation-8107808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/Q3UWP8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/B2MWM9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8107808 |
| http://purl.uniprot.org/uniprot/P14211 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8107808 |