| http://purl.uniprot.org/citations/8124718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8124718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8124718 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-4 (IL-4) treatment of 32D cells overexpressing insulin receptor substrate 1 (IRS-1) causes prompt tyrosine phosphorylation of IRS-1. Transfection of truncation mutants of the human IL-4 (huIL-4) receptor into 32D-IRS-1 cells demonstrated that the region from amino acid 437-557 is important for IL-4 signaling. This region of the IL-4 receptor (IL-4R) contains the motif 488PL-X4-NPXYXSXSD502 (insulin/IL-4R [I4R]) found in the insulin and insulin-like growth factor 1 receptors. Mutation of Y497 to F yielded receptors that caused little or no IRS-1 phosphorylation in response to huIL-4 when expressed in 32D-IRS-1 cells. Most cell lines expressing Y497F also failed to proliferate in response to huIL-4. Furthermore, a glutathione-S-transferase fusion protein containing the I4R motif-bound IRS-1, tyrosine kinase(s), and other unidentified phosphoproteins with molecular sizes of 140, 80, and 55 kd. Thus, the central tyrosine of the I4R motif has a major role in IL-4-mediated signal transduction in 32D cells."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90356-5"xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90356-5"xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "White M."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "White M."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Paul W.E."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Paul W.E."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Pierce J.H."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Pierce J.H."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Wang L.-M."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Wang L.-M."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Nelms K."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Nelms K."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Keegan A.D."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/author | "Keegan A.D."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/pages | "811-820"xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/pages | "811-820"xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/title | "An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth."xsd:string |
| http://purl.uniprot.org/citations/8124718 | http://purl.uniprot.org/core/title | "An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth."xsd:string |