| http://purl.uniprot.org/citations/8183915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8183915 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8183915 | http://www.w3.org/2000/01/rdf-schema#comment | "The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70 I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105. Here we show that alternative RNA splicing generates I kappa B gamma isoforms with properties different from those of p70. One 63-kDa isoform, termed I kappa B gamma-1, which lacks 59 amino acids C-terminal to ankyrin repeat 7, has a novel 35-amino acid C terminus encoded by an alternative reading frame of the p105 gene. A 55-kDa isoform, I kappa B gamma-2, lacks the 190 C-terminal amino acids of p70I kappa B gamma. In contrast to p70I kappa B gamma, which is a cytoplasmic protein, I kappa B gamma-1 is found in both the cytoplasm and nucleus, whereas I kappa B gamma-2 is predominantly nuclear. The I kappa B gamma isoforms also display differences in specificity and affinity for Rel/NF-kappa B proteins. While p70I kappa B gamma inhibits p50-, p65-, and c-Rel-mediated transactivation and/or DNA binding, both I kappa B gamma-1 and I kappa B gamma-2 are specific for p50 and have different affinities for this subunit. The absence in I kappa B gamma-1 and I kappa B gamma-2 of a protein kinase A site whose phosphorylation modulates p70I kappa B gamma inhibitory activity suggests that alternative RNA splicing may be used to generate I kappa B gamma isoforms that respond differently to intracellular signals."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.10.4367"xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.10.4367"xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/author | "Gerondakis S."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/author | "Gerondakis S."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/author | "Grumont R.J."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/author | "Grumont R.J."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/pages | "4367-4371"xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/pages | "4367-4371"xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/title | "Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/title | "Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities."xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/8183915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8183915 |
| http://purl.uniprot.org/citations/8183915 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8183915 |
| http://purl.uniprot.org/citations/8183915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8183915 |
| http://purl.uniprot.org/citations/8183915 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8183915 |
| http://purl.uniprot.org/uniprot/P25799 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8183915 |
| http://purl.uniprot.org/uniprot/P25799#attribution-1404FE69ACCCF981C0C978CF2DA494CD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8183915 |