| http://purl.uniprot.org/citations/8231246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8231246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8231246 | http://www.w3.org/2000/01/rdf-schema#comment | "The ETS family proteins have a conserved DNA-binding domain and act as transcription factors. Three domains have been recently defined in human ETS-1 proteins and their role could depend upon the nature of alternative transcripts according to whether they possess or lack DNA binding and/or transcriptional activation domain and also point mutation that could affect these important domains. Expression of ETS-1 gene is very complex and is controlled at several levels: the initiation of transcription, alternative splicing, post-translational modification, and protein stability. As a selection apparently exists for ETS-1 gene activation in hematopoietic cells, we investigated a relation between quantitative and qualitative ETS-1 expression and leukemogenesis. Using Northern blot, polymerase chain reaction (PCR), and single strand conformation polymorphism (SSCP) methods, we analyzed quantitative and qualitative ETS-1 expression in a variety of hematological pathologies and cell lines of different origin. Two ETS-1 transcripts of 6.8 and 2.7 kb, resulting from differential polyadenylation site utilization and exhibiting different stability, were observed. We identified, in a great number of patients, the four alternative ETS-1 products, but the relative extent significance of the four transcripts was very different from one patient to another. A non-conservative mutation observed in one case of T-cell acute lymphoblastic leukemia (T-ALL) and in the ETS-1 transactivation domain raised the question of suppressor activity for some ETS-1 products, as it is now known that activators and repressors can be encoded by the same gene and consistently co-expressed in vivo."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Galiegue-Zouitina S."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Galiegue-Zouitina S."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Kerckaert J.P."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Kerckaert J.P."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Quief S."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Quief S."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Loucheux-Lefebvre M.H."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Loucheux-Lefebvre M.H."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Collyn d'Hooghe M."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Collyn d'Hooghe M."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Lantoine D."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Lantoine D."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Szymiczek D."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/author | "Szymiczek D."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/pages | "1777-1785"xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/pages | "1777-1785"xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/title | "Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies."xsd:string |
| http://purl.uniprot.org/citations/8231246 | http://purl.uniprot.org/core/title | "Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies."xsd:string |