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http://purl.uniprot.org/citations/8242742http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8242742http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8242742http://www.w3.org/2000/01/rdf-schema#comment"Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGF beta and activin type II receptors, act as type I receptors for these factors. TSR-I is a type I receptor shared by TGF beta and activin, whereas ActR-I is an activin type I receptor. ActR-I, but not TSR-I, signals a particular transcriptional response in concert with activin type II receptors. The results indicate that type I receptors are transmembrane protein kinases that associate with type II receptors to generate diverse heteromeric serine/threonine kinase complexes of different signaling capacities."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(93)90488-c"xsd:string
http://purl.uniprot.org/citations/8242742http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(93)90488-c"xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Attisano L."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Attisano L."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Carcamo J."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Carcamo J."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Massague J."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Massague J."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Ventura F."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Ventura F."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Weis F.M."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Weis F.M."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Wrana J.L."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/author"Wrana J.L."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/pages"671-680"xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/pages"671-680"xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/title"Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."xsd:string
http://purl.uniprot.org/citations/8242742http://purl.uniprot.org/core/title"Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."xsd:string