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Genomic sequence of mouse COL1A1 encoding the collagen propeptides.

Fenton S.P., Lamande S.R., Hannagan M., Stacey A., Jaenisch R., Bateman J.F.

The nucleotide sequences of the mouse pro alpha 1(I) gene regions coding for the N- and C-propeptides is reported. The exon-intron structure was highly homologous to human COL1A1 and the deduced amino acid sequences of the N- and C-propeptides showed 67% and 91% identity with the human sequence. This gene sequence information will allow the production of specific gene mutations by site-directed mutagenesis to study the structure and function of these important propeptide domains.

Biochim. Biophys. Acta 1216:469-474(1993) [PubMed] [Europe PMC]

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