| http://purl.uniprot.org/citations/8305738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8305738 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the Caenorhabditis elegans gene sem-5 affect cell signaling processes involved in guiding a class of cell migrations and inducing vulval cell fates. The sem-5 sequence encodes a protein comprised almost exclusively of SH2 and SH3 domains (SH, src homology region) that are found together in many signaling proteins and nonreceptor tyrosine kinases. A human protein, GRB2, was identified by its ability to associate with the activated human epidermal growth factor receptor (hEGFR). The GRB2 and Sem-5 proteins share an identical architecture of their SH2 and SH3 domains and 58% amino acid sequence identity. Here we demonstrate that GRB2 and a Drosophila sem-5-like gene Drk can specifically rescue sem-5 mutants. We also show that Sem-5, like GRB2, can bind to the activated hEGFR in vitro. We further correlate the abilities of several mutant variants of GRB2 and Sem-5 to bind to the hEGFR in vitro with their abilities to functionally replace sem-5 in vivo. These data indicate that GRB2 and Drk are functional homologues of Sem-5 and demonstrate the high degree of conservation of both structure and function between signaling systems throughout evolution."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.4.11.1175"xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Daly R.J."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Pawson T."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Schlessinger J."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Kokel M."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Stern M.J."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Marengere L.E."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Lowenstein E.J."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Olivier P."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/author | "Batzer A."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/pages | "1175-1188"xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/title | "The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5."xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/8305738 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8305738 |
| http://purl.uniprot.org/citations/8305738 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8305738 |
| http://purl.uniprot.org/uniprot/P29355#attribution-C35A2F9FB368C2CB1AD8965D9046CA74 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8305738 |
| http://purl.uniprot.org/uniprot/#_Q08012-mappedCitation-8305738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8305738 |
| http://purl.uniprot.org/uniprot/#_P29355-mappedCitation-8305738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8305738 |
| http://purl.uniprot.org/uniprot/Q08012 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8305738 |
| http://purl.uniprot.org/uniprot/P29355 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8305738 |