| http://purl.uniprot.org/citations/8312229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8312229 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10 was originally described as an inhibitory factor produced by murine Th2 lymphocytes that suppresses IFN-gamma production by activated murine Th1 lymphocytes. In this study, we have analyzed the effect of human IL-10 on human T cell death induced by IL-2 deprivation. IL-2-dependent T lymphocytes rapidly die when deprived of IL-2. This cell death was found to involve loss of cell volume, chromatin condensation, and DNA fragmentation, all characteristic of apoptosis. After 2 days incubation in culture medium without IL-2, the viability of TM11 cells (a tetanus toxoid-specific T cell line) and of activated peripheral blood T cells decreased from > 98% to 34.3 (+/- 2.9) and 39.7 (+/-5.5%) respectively. Addition of purified human IL-10 (100 U/ml) to these IL-2-starved cells significantly improved cell viability (66.0 +/- 6.0 and 73.1 +/-12.3% respectively, P = 0.0051). This protective effect of IL-10 was dose-dependent and was neutralized by the anti-human IL-10 mAb 19F1. It was neither accompanied by T cell growth stimulation as judged by [3H]thymidine incorporation nor neutralized by anti-IL-2 or anti-IL-2 receptor (CD25) antibodies. Analysis of DNA after separation on agarose gels revealed that IL-10 inhibits DNA fragmentation in IL-2-starved T cells. T cells protected from death by IL-10 were indistinguishable from IL-10-untreated viable T cells in the ability to proliferate in response to IL-2. Thus, another property of IL-10 is to promote the survival of IL-2-dependent T cells otherwise destined to die by apoptosis."xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/5.12.1599"xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/author | "Tosato G."xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/author | "Cherney B."xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/author | "Taga K."xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/pages | "1599-1608"xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/title | "IL-10 inhibits apoptotic cell death in human T cells starved of IL-2."xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/8312229 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8312229 |
| http://purl.uniprot.org/citations/8312229 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8312229 |
| http://purl.uniprot.org/uniprot/P22301#attribution-9DC8B2B3B2AF8B05932617906899C925 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8312229 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-8312229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8312229 |
| http://purl.uniprot.org/uniprot/#_Q3U879-mappedCitation-8312229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8312229 |
| http://purl.uniprot.org/uniprot/#_P18893-mappedCitation-8312229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8312229 |
| http://purl.uniprot.org/uniprot/A0A7R8GUQ3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8312229 |
| http://purl.uniprot.org/uniprot/P18893 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8312229 |
| http://purl.uniprot.org/uniprot/Q3U879 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8312229 |