| http://purl.uniprot.org/citations/8376943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8376943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8376943 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we have used a newly generated monoclonal antibody (mAb C1.7) to identify a novel 38-kD signal-transducing surface molecule (p38) expressed by lymphocyte subsets capable of cell-mediated cytotoxicity. Virtually all CD16+/CD56+ natural killer (NK) cells and approximately half of CD8+ (T cell receptor [TCR] alpha/beta+) T cells and TCR-gamma/delta+ T cells express the p38 surface molecule. Stimulation of p38 on NK cells with mAb C1.7 activated cytotoxicity, induced lymphokine production, and initiated polyphosphoinositol turnover and [Ca2+]i increases. Unlike other NK cell surface molecules that activate cytotoxicity, p38 stimulation did not result in the release of the granule enzyme N-carbobenzoxy-L-thiobenzyl ester-esterase even under conditions in which mAb C1.7 induced NK cell-mediated redirected lysis of Fc gamma R+ target cells. Activated (recombinant interleukin 2 [rIL-2], 5 d) CD8+ T cells mediated non-major histocompatibility complex (MHC)-restricted cytotoxicity, and the CD8+/p38+ subset contained the overwhelming majority of this activity. F(ab')2 fragments of mAb C1.7 inhibited non-MHC-restricted cytotoxicity mediated by resting NK cells and rIL-2-cultured T cells but did not affect spontaneous cytotoxicity mediated by activated, cultured NK cells. Taken as a whole, our results suggest that p38 may have a direct role in the recognition, signal transduction, and/or lytic mechanisms of non-MHC-restricted cytotoxicity."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.178.4.1397"xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.178.4.1397"xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/author | "Trinchieri G."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/author | "Trinchieri G."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/author | "Valiante N.M."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/author | "Valiante N.M."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/pages | "1397-1406"xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/pages | "1397-1406"xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/title | "Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/title | "Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/8376943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8376943 |
| http://purl.uniprot.org/citations/8376943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8376943 |
| http://purl.uniprot.org/citations/8376943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8376943 |
| http://purl.uniprot.org/citations/8376943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8376943 |
| http://purl.uniprot.org/uniprot/Q9BZW8 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8376943 |
| http://purl.uniprot.org/uniprot/Q9BZW8#attribution-5268882504F0714C098F6F69B0DECEB9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8376943 |