| http://purl.uniprot.org/citations/8382613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8382613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8382613 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase implicated in the cellular response to insulin. The enzyme is the mammalian homologue of the zeste-white3 (shaggy) homeotic gene of Drosophila melanogaster and has been implicated in the regulation of the c-Jun/AP-1 transcription factor. In mammals this protein serine kinase is encoded by two related genes termed GSK-3 alpha and beta. Here, we demonstrate that these two proteins and the fruit fly protein are phosphorylated on tyrosine in vivo. Moreover, GSK-3 beta activity and function are shown to be dependent on tyrosine phosphorylation. The modified tyrosine residue is conserved in all members of the GSK-3 family and is equivalent to that required for activity by mitogen-activated protein (MAP) kinases. However, unlike MAP kinases, GSK-3 is highly phosphorylated on tyrosine and thus active in resting cells."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1993.tb05715.x"xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1993.tb05715.x"xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Hughes K."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Hughes K."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Plyte S.E."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Plyte S.E."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Totty N.F."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Totty N.F."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Nikolakaki E."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/author | "Nikolakaki E."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/pages | "803-808"xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/pages | "803-808"xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/title | "Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/title | "Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/8382613 | http://purl.uniprot.org/core/volume | "12"xsd:string |