| http://purl.uniprot.org/citations/8397373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8397373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8397373 | http://www.w3.org/2000/01/rdf-schema#comment | "Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity between the activin receptor type II and Daf-1. The cDNA clones for ALK-1, -2 and -3 encode complete proteins of 503, 509 and 532 amino acids respectively. The ALK-4 cDNA is incomplete and the predicted protein of 383 amino acids has a truncated extracellular domain. The ALKs share similar domain structures, comprising predicted signal sequences at the N-terminals, followed by hydrophilic cysteine-rich ligand-binding domains, single hydrophobic transmembrane regions and C-terminal intracellular portions that consist almost entirely of putative serine/threonine kinase domains. The ALKs have approximately 40% sequence identity to activin receptors type II and IIB, transforming growth factor-beta (TGF-beta) type II receptor and Daf-1 in the kinase domains. However, the sequence identities are higher (60-79%) between ALK-1, -2, -3 and -4, suggesting that they form a subfamily among the putative receptor serine/threonine kinases. The extracellular domains of ALKs show only little sequence identity to other putative receptor serine/threonine kinases, but the cysteine residues are conserved. Their structural properties suggest that ALK-1 to -4 are receptors that may bind ligands that are members of the TGF-beta superfamily. The expression of mRNA in human tissues varied for the different ALKs; ALK-2 and ALK-4 showed ubiquitous tissue expression patterns, whereas the distribution of ALK-1 and ALK-3 varied strongly between different tissues with more restricted expression patterns. These results suggest that each ALK may have different in vivo functions."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Franzen P."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Franzen P."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Heldin C.-H."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Heldin C.-H."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Ichijo H."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Saras J."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Saras J."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Schulz P."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Schulz P."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Toyoshima H."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "Toyoshima H."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/pages | "2879-2887"xsd:string |
| http://purl.uniprot.org/citations/8397373 | http://purl.uniprot.org/core/pages | "2879-2887"xsd:string |