| http://purl.uniprot.org/citations/8405995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8405995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8405995 | http://www.w3.org/2000/01/rdf-schema#comment | "The E2F transcription factor has been implicated in the regulation of genes whose products are involved in cell proliferation. Two proteins have recently been identified with E2F-like properties. One of these proteins, E2F-1, has been shown to mediate E2F-dependent trans-activation and to bind the hypophosphorylated form of the retinoblastoma protein (pRB). The other protein, murine DP-1, was purified from an E2F DNA-affinity column, and it was subsequently shown to bind the consensus E2F DNA-binding site. To study a possible interaction between E2F-1 and DP-1, we have now isolated a cDNA for the human homolog of DP-1. Human DP-1 and E2F-1 associate both in vivo and in vitro, and this interaction leads to enhanced binding to E2F DNA-binding sites. The association of E2F-1 and DP-1 leads to cooperative activation of an E2F-responsive promoter. Finally, we demonstrate that E2F-1 and DP-1 association is required for stable interaction with pRB in vivo and that trans-activation by E2F-1/DP-1 heterodimers is inhibited by pRB. We suggest that "E2F" is the activity that is formed when an E2F-1-related protein and a DP-1-related protein dimerize."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.7.10.1850"xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.7.10.1850"xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Harlow E."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Harlow E."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Wu C.-L."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Wu C.-L."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Helin K."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Helin K."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Fattaey A.R."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Fattaey A.R."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Lees J.A."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Lees J.A."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Dynlacht B.D."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Dynlacht B.D."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Ngwu C."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/author | "Ngwu C."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/pages | "1850-1861"xsd:string |
| http://purl.uniprot.org/citations/8405995 | http://purl.uniprot.org/core/pages | "1850-1861"xsd:string |