http://purl.uniprot.org/citations/8464713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8464713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8464713 | http://www.w3.org/2000/01/rdf-schema#comment | "The DNA-dependent protein kinase (DNA-PK) phosphorylates a number of transcription factors. Here, we show that the DNA-PK modifies c-Jun in vitro and that serine residue 249 (Ser-249) is required for phosphorylation to occur. This residue corresponds to one of three sites of c-Jun that are phosphorylated in vivo and which negatively regulate c-Jun DNA binding in vitro. However, we find that phosphorylation of c-Jun by the DNA-PK does not interfere with DNA binding, indicating that phosphorylation at other sites is required for this effect. Mutagenesis of the phosphorylated region of c-Jun reveals that the primary amino acid sequence recognised by the DNA-PK consists of the sequence Ser-Gln, and that adjacent acidic residues potentiate kinase activity. Furthermore, when this site is placed within the context of a second protein, it confers DNA-PK directed phosphorylation upon that protein. Our findings will facilitate identification of DNA-PK phosphorylation sites in other transcription factors."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/21.5.1289"xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/21.5.1289"xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Kouzarides T."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Bannister A.J."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Bannister A.J."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Gottlieb T.M."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/author | "Gottlieb T.M."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/pages | "1289-1295"xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/pages | "1289-1295"xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/title | "c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/title | "c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif."xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/volume | "21"xsd:string |
http://purl.uniprot.org/citations/8464713 | http://purl.uniprot.org/core/volume | "21"xsd:string |
http://purl.uniprot.org/citations/8464713 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8464713 |
http://purl.uniprot.org/citations/8464713 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8464713 |