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http://purl.uniprot.org/citations/8505288http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8505288http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8505288http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Citation
http://purl.uniprot.org/citations/8505288http://www.w3.org/2000/01/rdf-schema#comment"Botulinum neurotoxin serotype F contains the zinc binding motif of zinc endopeptidases. Atomic adsorption analysis of highly purified toxin preparation revealed the presence of one atom of zinc per molecule of toxin, which could be removed with EDTA or o-phenanthroline. The light chain of the neurotoxin was shown to have a zinc-dependent protease activity specific for VAMP/synaptobrevin, an integral membrane protein of synaptic vesicles. Both isoforms of rat VAMP were cleaved at the same site corresponding to the single Gln-Lys peptide bond present in their sequences. This proteolytic activity was inhibited by EDTA, o-phenanthroline, and captopril as well as by VAMP peptides spanning the cleavage site."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(19)50230-7"xsd:string
http://purl.uniprot.org/citations/8505288http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(19)50230-7"xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Montecucco C."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Montecucco C."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Rossetto O."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Rossetto O."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Schiavo G."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Schiavo G."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Shone C.C."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Shone C.C."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Alexander F.C."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/author"Alexander F.C."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/pages"11516-11519"xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/pages"11516-11519"xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/title"Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/title"Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin."xsd:string
http://purl.uniprot.org/citations/8505288http://purl.uniprot.org/core/volume"268"xsd:string