| http://purl.uniprot.org/citations/8521819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8521819 | http://www.w3.org/2000/01/rdf-schema#comment | "The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence junction protein catenin. Here we show that overexpression of APC blocks serum-induced cell cycle progression from G0/G1 to the S phase. Mutant APCs identified in FAP and/or colorectal tumours were less inhibitory and partially obstructed the activity of the normal APC. The cell-cycle blocking activity of APC was alleviated by the overexpression of cyclin E/CDK2 or cyclin D1/CDK4. Consistent with this result, kinase activity of CDK2 was significantly down-regulated in cells overexpressing APC although its synthesis remained unchanged, while CDK4 activity was barely affected. These results suggest that APC may play a role in the regulation of the cell cycle by negatively modulating the activity of cyclin-CDK complexes."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1995.tb00249.x"xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Toyoshima K."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Matsumine A."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Kuroda T."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Baeg G.H."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Bhattacharjee R.N."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/author | "Miyashiro I."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/pages | "5618-5625"xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/title | "The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase."xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/8521819 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8521819 |
| http://purl.uniprot.org/citations/8521819 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8521819 |
| http://purl.uniprot.org/uniprot/P25054#attribution-BC18E81A233B4C679648306F70EC2973 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8521819 |