| http://purl.uniprot.org/citations/8530500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8530500 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of the T cell receptor (TCR).CD3 complex results in the induction of multiple intracellular events, with protein tyrosine kinases playing a pivotal role in their initiation. Biochemical studies also exist suggesting the involvement of heterotrimeric GTP-binding proteins (G proteins); however, the functional consequence of this participation in TCR.CD3-mediated signaling is unresolved. Here, we report TCR.CD3-mediated guanine nucleotide exchange among the 42-kDa G protein alpha subunits of the G alpha q/11 family, their physical association with CD3 epsilon, and the G alpha 11-dependent activation of phospholipase C beta. Protein tyrosine kinase inhibitors, however, abrogate TCR.CD3-mediated G protein activation. Quite interesting is the observation that cells transfected with a function-deficient mutant of G alpha 11 display diminished tyrosine phosphorylation of TCR.CD3 zeta and epsilon chains, as well as ZAP-70, upon anti-CD3 antibody triggering. These data indicate the involvement of the G alpha q/11 family in TCR.CD3 signaling at a step proximal to the receptor and suggest a reciprocal regulation between tyrosine kinases and G proteins in T cells."xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.270.51.30635"xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/author | "McGuire K.L."xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/author | "Tsoukas C.D."xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/author | "Kabouridis P.S."xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/author | "Stanners J."xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/date | "1995"xsd:gYear |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/pages | "30635-30642"xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/title | "Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling."xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://purl.uniprot.org/core/volume | "270"xsd:string |
| http://purl.uniprot.org/citations/8530500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8530500 |
| http://purl.uniprot.org/citations/8530500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8530500 |
| http://purl.uniprot.org/uniprot/P07766#attribution-F7BCB2BD51F71B9747F0E715156E3B69 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8530500 |
| http://purl.uniprot.org/uniprot/P29992#attribution-F7BCB2BD51F71B9747F0E715156E3B69 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8530500 |