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http://purl.uniprot.org/citations/8532022http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8532022http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8532022http://www.w3.org/2000/01/rdf-schema#comment"

Background

Graft-versus-host disease (GVHD) can be a major complication of allogeneic bone marrow transplantation even when the donor and recipient are siblings and share identical major histocompatibility antigens. The explanation may be a mismatch of minor histocompatibility antigens. We previously characterized five minor histocompatibility antigens, HA-1, 2, 3, 4, and 5, that are recognized by T cells in association with the major histocompatibility antigens HLA-A1 an A2.

Methods

We collected peripheral-blood leukocytes from 148 bone marrow recipients and their sibling donors, who were genotypically HLA identical. Fifty pairs were positive for HLA-A1, 117 were positive for HLA-A2, and 19 were positive for both. The pairs were typed with cytotoxic-T-cell clones specific for minor histocompatibility antigens HA-1, 2, 3, 4, and 5.

Results

Mismatches of HA-3 were equally distributed among recipients in whom GVHD developed and those in whom it did not. By contrast, a mismatch of only HA-1 was significantly correlated with GVHD of grade II or higher (odds ratio, infinity; P = 0.02) in adults. One or more mismatches of HA-1, 2, 4, and 5 were also significantly associated with GVHD (odds ratio, infinity; P = 0.006) in adults. These associations were not observed in children.

Conclusions

A mismatch of minor histocompatibility antigen HA-1 can cause GVHD in adult recipients of allogeneic bone marrow from HLA-identical donors. Prospective HA-1 typing may improve donor selection and identify recipients who are at high risk for GVHD."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.org/dc/terms/identifier"doi:10.1056/nejm199602013340501"xsd:string
http://purl.uniprot.org/citations/8532022http://purl.org/dc/terms/identifier"doi:10.1056/nejm199602013340501"xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Blokland E."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Blokland E."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Falkenburg J.H."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Falkenburg J.H."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Goulmy E."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Goulmy E."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Gratwohl A."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Gratwohl A."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Pool J."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Pool J."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Schipper R."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Schipper R."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Vogelsang G.B."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Vogelsang G.B."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Vossen J."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"Vossen J."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"van Houwelingen H.C."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"van Houwelingen H.C."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"van Rood J.J."xsd:string
http://purl.uniprot.org/citations/8532022http://purl.uniprot.org/core/author"van Rood J.J."xsd:string
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