| http://purl.uniprot.org/citations/8551236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8551236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8551236 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating data show that the tyrosine protein kinase Zap-70 plays an essential role in T cell receptor-mediated signal transduction. However, the model of action, as well as the physiologically relevant substrates of Zap-70, have not been determined. We have attempted to identify a 120-kD tyrosine-phosphorylated protein (p120) that associates with Zap-70 in activated T lymphocytes. The results of our analyses showed that p120 is largely encoded by the c-cbl protooncogene. Furthermore, the association of Zap-70 with c-Cbl was shown to be induced by T cell receptor stimulation, implying that it required posttranslational modification of one or both of these products. FynT, but not Lck, also associated with c-Cbl in activated T cells. Finally, using a heterologous system, it was demonstrated that the ability of Zap-70 to cause tyrosine phosphorylation of p120c-cbl was dependent on Lck- or FynT-mediated signals. As c-Cbl can associate with several other signaling molecules, it may couple Zap-70 to downstream effectors during T cell activation."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.183.1.301"xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.183.1.301"xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Weil R."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Weil R."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Davidson D."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Fournel M."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Fournel M."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/pages | "301-306"xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/pages | "301-306"xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/title | "Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/title | "Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/8551236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8551236 |
| http://purl.uniprot.org/citations/8551236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8551236 |