| http://purl.uniprot.org/citations/8563754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8563754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8563754 | http://www.w3.org/2000/01/rdf-schema#comment | "The t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0296-159"xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0296-159"xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Toyama K."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Toyama K."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Morris C."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Morris C."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Ohyashiki K."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Ohyashiki K."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Borrow J."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Borrow J."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Housman D.E."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Housman D.E."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Williams A.J."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Williams A.J."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Katz F."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Katz F."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Becher R."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Becher R."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Dube I."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Dube I."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Stanton V.P."xsd:string |
| http://purl.uniprot.org/citations/8563754 | http://purl.uniprot.org/core/author | "Stanton V.P."xsd:string |