| http://purl.uniprot.org/citations/8603916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8603916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8603916 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the Caenorhabditis elegans gene unc-89 result in nematodes having disorganized muscle structure in which thick filaments are not organized into A-bands, and there are no M-lines. Beginning with a partial cDNA from the C. elegans sequencing project, we have cloned and sequenced the unc-89 gene. An unc-89 allele, st515, was found to contain an 84-bp deletion and a 10-bp duplication, resulting in an in-frame stop codon within predicted unc-89 coding sequence. Analysis of the complete coding sequence for unc-89 predicts a novel 6,632 amino acid polypeptide consisting of sequence motifs which have been implicated in protein-protein interactions. UNC-89 begins with 67 residues of unique sequences, SH3, dbl/CDC24, and PH domains, 7 immunoglobulins (Ig) domains, a putative KSP-containing multiphosphorylation domain, and ends with 46 Ig domains. A polyclonal antiserum raised to a portion of unc-89 encoded sequence reacts to a twitchin-sized polypeptide from wild type, but truncated polypeptides from st515 and from the amber allele e2338. By immunofluorescent microscopy, this antiserum localizes to the middle of A-bands, consistent with UNC-89 being a structural component of the M-line. Previous studies indicate that myofilament lattice assembly begins with positional cues laid down in the basement membrane and muscle cell membrane. We propose that the intracellular protein UNC-89 responds to these signals, localizes, and then participates in assembling an M-line."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.132.5.835"xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.132.5.835"xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Borodovsky M."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Borodovsky M."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Benian G.M."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Benian G.M."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Tinley T.L."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/author | "Tinley T.L."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/pages | "835-848"xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/pages | "835-848"xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains."xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/8603916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8603916 |
| http://purl.uniprot.org/citations/8603916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8603916 |