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http://purl.uniprot.org/citations/8620536http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8620536http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8620536http://www.w3.org/2000/01/rdf-schema#comment"Using a yeast one-hybrid screen with a DNA-bound Ets-1 protein, we have identified MafB, an AP-1 like protein, as a direct interaction partner. MafB is specifically expressed in myelomonocytic cells and binds to the DNA-binding domain of Ets-1 via its basic region or leucine-zipper domain. Furthermore, it represses Ets-1 transactivation of synthetic promoters containing Ets binding sites and inhibits Ets-1-mediated transactivation of the transferrin receptor, which is known to be essential for erythroid differentiation. Accordingly, overexpression of MafB in an erythroblast cell line down-regulates the endogenous transferrin receptor gene and inhibits differentiation without affecting cell proliferation. These results highlight the importance of inhibitory interactions between transcription factors in regulating lineage-specific gene expression."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)81081-8"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.org/dc/terms/identifier"doi:10.1016/s0092-8674(00)81081-8"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Graf T."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Graf T."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Frampton J."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Frampton J."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Tekotte H."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Tekotte H."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Sieweke M.H."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/author"Sieweke M.H."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/date"1996"xsd:gYear
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/pages"49-60"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/pages"49-60"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/title"MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/title"MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation."xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/volume"85"xsd:string
http://purl.uniprot.org/citations/8620536http://purl.uniprot.org/core/volume"85"xsd:string
http://purl.uniprot.org/citations/8620536http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8620536
http://purl.uniprot.org/citations/8620536http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8620536