http://purl.uniprot.org/citations/8620536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8620536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8620536 | http://www.w3.org/2000/01/rdf-schema#comment | "Using a yeast one-hybrid screen with a DNA-bound Ets-1 protein, we have identified MafB, an AP-1 like protein, as a direct interaction partner. MafB is specifically expressed in myelomonocytic cells and binds to the DNA-binding domain of Ets-1 via its basic region or leucine-zipper domain. Furthermore, it represses Ets-1 transactivation of synthetic promoters containing Ets binding sites and inhibits Ets-1-mediated transactivation of the transferrin receptor, which is known to be essential for erythroid differentiation. Accordingly, overexpression of MafB in an erythroblast cell line down-regulates the endogenous transferrin receptor gene and inhibits differentiation without affecting cell proliferation. These results highlight the importance of inhibitory interactions between transcription factors in regulating lineage-specific gene expression."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81081-8"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81081-8"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Graf T."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Graf T."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Frampton J."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Frampton J."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Tekotte H."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Tekotte H."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Sieweke M.H."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/author | "Sieweke M.H."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/pages | "49-60"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/pages | "49-60"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/title | "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/title | "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation."xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/volume | "85"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://purl.uniprot.org/core/volume | "85"xsd:string |
http://purl.uniprot.org/citations/8620536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8620536 |
http://purl.uniprot.org/citations/8620536 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8620536 |