http://purl.uniprot.org/citations/8622660 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/8622660 | http://www.w3.org/2000/01/rdf-schema#comment | "We demonstrate that ATF3, a member of the ATF/CREB family of transcription factors, is induced in a variety of stressed tissues: mechanically injured liver, toxin-injured liver, blood-deprived heart, and postseizure brain. We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional heterodimer with ATF3: the heterodimer, in contrast to the ATF3 homodimer, does not bind to the ATF/cyclic AMP response element consensus site and does not repress transcription. Interestingly, ATF3 and gadd153/Chop10 are expressed in inverse but overlapping manners during the liver's response to carbon tetrachloride (CCl4): the level of gadd153/Chop10 mRNA is high in the normal liver and greatly decreases upon CCl4 treatment; the level of ATF3 mRNA, on the other hand, is low in the normal liver and greatly increases upon CCl4 treatment. We hypothesize that in nonstressed liver, gadd153/Chop10 inhibits the limited amount of ATF3 by forming an inactive heterodimer with it, whereas in CCl4-injured liver, the synthesis of gadd153/Chop10 is repressed, allowing the induced ATF3 to function."xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.16.3.1157"xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/author | "Wolfgang C.D."xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/author | "Hai T."xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/author | "Chen B.P."xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/pages | "1157-1168"xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/title | "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10."xsd:string |
http://purl.uniprot.org/citations/8622660 | http://purl.uniprot.org/core/volume | "16"xsd:string |
http://purl.uniprot.org/citations/8622660 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8622660 |
http://purl.uniprot.org/citations/8622660 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8622660 |
http://purl.uniprot.org/uniprot/P18847#attribution-0DB95CE8153CEE10C0FF719E2EBA091D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622660 |
http://purl.uniprot.org/uniprot/P18847#attribution-2A8D19CFEE37B54AB687CE407C80BC7A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622660 |
http://purl.uniprot.org/uniprot/P18847#attribution-4E92AAED902B6CD4D20310BD5069D43A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622660 |
http://purl.uniprot.org/uniprot/P18847#attribution-6110997D9D755650FC4386062170A194 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622660 |
http://purl.uniprot.org/uniprot/P35638#attribution-4E92AAED902B6CD4D20310BD5069D43A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622660 |
http://purl.uniprot.org/uniprot/P35638#attribution-6110997D9D755650FC4386062170A194 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8622660 |