| http://purl.uniprot.org/citations/8642349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8642349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8642349 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel human CC chemokine complementary DNA was identified in a library constructed from human fetal RNA, cloned into a baculovirus vector, and expressed in Sf9 insect cells. The mature recombinant protein that was released had the NH2-terminal sequence pyro-QPDALNVPSTC...and consisted of 75 amino acids. Minor amounts of two variants of 77 and 82 residues (NH2 termini: LAQPDA...and FNPQGLAQPDA...) were released as well. The novel chemokine was designated monocyte chemotactic protein 4 (MCP-4) and the variants were designated (LA)MCP-4 and (FNPQGLA)MCP-4. MCP-4 shares the pyroglutamic acidproline NH2-terminal motif and 56-61% sequence identity with the three known monocyte chemotactic proteins and is 60% identical to eotaxin. It has marked functional similarities to MCP-3 and eotaxin. Like MCP-3, MCP-4 is a chemoattractant of high efficacy for monocytes and T lymphocytes. On these cells, it binds to receptors that recognize MCP-1, MCP-3, and RANTES. On eosinophils, MCP-4 has similar efficacy and potency as MCP-3, RANTES, and cotaxin. It shares receptors with eotaxin and shows full cross-desensitization with this cosinophil-selective chemokine. Of the two variants, only (LA)MCP-4 could be purified in sufficient quantities for testing and was found to be at least 30-fold less potent than MCP-4 itself. This suggests that the 75-residue form with the characteristic NH2 terminus of an MCP is the biologically relevant species."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.183.5.2379"xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.183.5.2379"xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Thelen M."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Thelen M."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Uguccioni M."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Uguccioni M."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Baggiolini M."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Baggiolini M."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Dewald B."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Dewald B."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Forssmann U."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Forssmann U."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Garotta G."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Garotta G."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Kreider B."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Kreider B."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Lima S.H."xsd:string |
| http://purl.uniprot.org/citations/8642349 | http://purl.uniprot.org/core/author | "Lima S.H."xsd:string |