| http://purl.uniprot.org/citations/8652841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8652841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8652841 | http://www.w3.org/2000/01/rdf-schema#comment | "Translocations involving the BCL-6 gene are common in the diffuse large cell subtype of non-Hodgkin's lymphoma. Invariably, the BCL-6 coding region is intact, but its 5' untranslated region is replaced with sequences from the translocation partner. The present study shows that BCL-6 expression is regulated in lymphocytes during mitogenic stimulation. Resting B and T lymphocytes contain high levels of BCL-6 mRNA. Stimulation of mouse B cells with anti-IgM or IgD antibodies, bacterial lipopolysaccharide, phorbol 12-myristate 13-acetate plus ionomycin, or CD40 ligand led to a five-fold to 35-fold decrease in BCL-6 mRNA levels. Similar downregulation of BCL-6 mRNA was seen in human B cells stimulated with Staphylococcus aureus plus interleukin-2 or anti-IgM antibodies and in human T lymphocytes stimulated with phytohemagglutinin. BCL-6 mRNA levels began to decrease 8 to 16 hours after stimulation, before cells entered S phase. Although polyclonal activation of B cells in vitro invariably decreased BCL-6 MRNA expression, activated B cells from human germinal centers expressed BCL-6 mRNA at levels comparable to the levels in resting B cells. Despite these similar mRNA levels, BCL-6 protein expression was threefold to 34-fold higher in germinal center B cells than in resting B cells, suggesting that BCL-6 protein levels are controlled by translational or posttranslational mechanisms. These observations suggest that the germinal center reaction provides unique activation signals to B cells that allow for continued, high-level BCL-6 expression."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Jain A."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Jain A."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Kehry M.R."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Kehry M.R."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Allman D."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Allman D."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Dent A."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Dent A."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Maile R.R."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Maile R.R."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Selvaggi T."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/author | "Selvaggi T."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/pages | "5257-5268"xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/pages | "5257-5268"xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/title | "BCL-6 expression during B-cell activation."xsd:string |
| http://purl.uniprot.org/citations/8652841 | http://purl.uniprot.org/core/title | "BCL-6 expression during B-cell activation."xsd:string |