| http://purl.uniprot.org/citations/8663478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8663478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8663478 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet-derived growth factor (PDGF) induces the expression of human stromelysin-1, a matrix metalloproteinase involved in tumor invasion and metastasis. Here it is shown that stromelysin-1 gene induction by PDGF depends on Ras and involves three previously identified promoter elements (the stromelysin-1 PDGF-responsive element (SPRE) site, the two head-to-head polyomavirus enhancer A-binding protein-3 (PEA3) sites, and the activator protein-1 (AP-1) binding site). During mitogenic induction, these responsive elements appear to be organized in two independent transcriptional units, SPRE-AP-1 and PEA3-AP-1, which result from specific element cross-talking. Interestingly, expression of a dominant negative mutant of Raf-1 significantly interfered with the induction through PEA3-AP-1 but not with that operating through SPRE-AP-1. Conversely, only the induction operating through SPRE-AP-1 was affected significantly by the expression of a dominant negative mutant of the atypical lambda/iota protein kinase C (lambda/iotaPKC). These data strongly suggest that the signal triggered by PDGF flows through Ras and bifurcates toward two distinct pathways, one operating through Raf and involving PEA3-AP-1 and the other one Raf-independent, operating through lambda/iotaPKC and SPRE-AP-1. Furthermore, we present evidence suggesting that the novel SPRE-binding transcription factor SPBP cross-couples with c-Jun to transactivate the SPRE site."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.30.18231"xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.271.30.18231"xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Sanz L."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Sanz L."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Kirstein M."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Kirstein M."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Saus J."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/author | "Saus J."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/pages | "18231-18236"xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/pages | "18231-18236"xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/title | "Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/title | "Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene."xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/volume | "271"xsd:string |
| http://purl.uniprot.org/citations/8663478 | http://purl.uniprot.org/core/volume | "271"xsd:string |