| http://purl.uniprot.org/citations/8666233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8666233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8666233 | http://www.w3.org/2000/01/rdf-schema#comment | "CDC37, an essential gene in Saccharomyces cerevisiae, interacts genetically with multiple protein kinases and is required for production of Cdc28p/cyclin complexes through an unknown mechanism. We have identified mammalian p50Cdc37 as a protein kinase-targeting subunit of the molecular chaperone Hsp90. Previously, p50 was observed in complexes with pp60v-src and Raf-1, but its identity and function have remained elusive. In mouse fibroblasts, a primary target of Cdc37 is Cdk4. This kinase is activated by D-type cyclins and functions in passage through G1. In insect cells, Cdc37 is sufficient to target Hsp90 to Cdk4 and both in vitro and in vivo, Cdc37/Hsp90 associates preferentially with the fraction of Cdk4 not bound to D-type cyclins. Cdc37 is coexpressed with cyclin Dl in cells undergoing programmed proliferation in vivo, consistent with a positive role in cell cycle progression. Pharmacological inactivation of Cdc37/Hsp90 function decreases the half-life of newly synthesized Cdk4, indicating a role for Cdc37/Hsp90 in Cdk4 stabilization. This study suggests a general role for p50Cdc37 in signaling pathways dependent on intrinsically unstable protein kinases and reveals a previously unrecognized chaperone-dependent step in the production of Cdk4/cyclin D complexes."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.10.12.1491"xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.10.12.1491"xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Parker S.B."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Parker S.B."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Harper J.W."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Leng X."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Leng X."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Stepanova L."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/author | "Stepanova L."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/date | "1996"xsd:gYear |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/pages | "1491-1502"xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/pages | "1491-1502"xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/title | "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/title | "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4."xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/8666233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8666233 |
| http://purl.uniprot.org/citations/8666233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8666233 |